l‐citrulline prevents asymmetric dimethylarginine‐mediated reductions in nitric oxide and nitrosative stress in primary human airway epithelial cells
Clinical & Experimental Allergy2016Vol. 47(2), pp. 190–199
Citations Over TimeTop 14% of 2016 papers
Daniel Winnica, Loretta G. Que, Cynthia W. Baffi, Hartmut Grasemann, Karoline Fiedler, Zhen Yang, Emily Etling, Karen Wasil, Sally E. Wenzel, Bridget Freeman, Fernando Holguín
Abstract
Increasing ADMA reduces NO formation and increases oxidative and nitrosative stress in airway epithelial cells. l-citrulline supplementation restores NO formation, while preventing nitrosative stress. These results, suggest that l-citrulline supplementation may indeed be a powerful approach to restore airway NO production and may have a therapeutic potential in diseases in which there is a defective production of NO.
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