Features of asthma which provide meaningful insights for understanding the disease heterogeneity
Clinical & Experimental Allergy2017Vol. 48(1), pp. 39–47
Citations Over TimeTop 10% of 2017 papers
Matea Deliu, Tolga S. Yavuz, Matthew Sperrin, Danielle Belgrave, Ümit Murat Şahiner, Cansın Saçkesen, Ömer Kalaycı, Adnan Ćustović
Abstract
An integrative approach of blending the data with clinical expert domain knowledge identified four features, which may be informative for ascertaining asthma endotypes. These findings suggest that variables which are key determinants of asthma presence, severity, or control may not be the most informative for determining asthma subtypes. Our results indicate that exacerbation-prone asthma may be a separate asthma endotype and that severe asthma is not a single entity, but an extreme end of the spectrum of several different asthma endotypes.
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