2S protein Ara h 7.0201 has unique epitopes compared to other Ara h 7 isoforms and is comparable to 2S proteins Ara h 2 and 6 in basophil degranulation capacity
Clinical & Experimental Allergy2018Vol. 48(7), pp. 890–897
Citations Over TimeTop 18% of 2018 papers
Simone M. Hayen, Anna M. Ehlers, Constance F. den Hartog Jager, Johan Garssen, Edward F. Knol, André C. Knulst, Waltraud Suer, Linette E. M. Willemsen, Henny G. Otten
Abstract
The majority of peanut-allergic patients are sensitized to isoform Ara h 7.0201, which is functionally as active as Ara h 2.0201 and 6.01. Unique epitopes are most likely located in the C-terminus or an allergenic loop region which is a known allergenic epitope region for Ara h 2.0201 and 6.01. Due to its unique epitopes and allergenicity, it is an interesting candidate to improve the diagnostic accuracy for peanut allergy.
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