Genome‐wide association study of inhaled corticosteroid response in admixed children with asthma
Clinical & Experimental Allergy2019Vol. 49(6), pp. 789–798
Citations Over TimeTop 10% of 2019 papers
Natalia Hernandez‐Pacheco, Niloufar Farzan, Ben Francis, Leila Karimi, Katja Repnik, Susanne J. H. Vijverberg, Patrícia Soares, Maximilian Schieck, Mario Gorenjak, Erick Forno, Celeste Eng, Sam S. Oh, Lina Pérez‐Méndez, Vojko Berce, Roger Tavendale, Lesly‐Anne Samedy, Scott Hunstman, Donglei Hu, Kelley Meade, Harold J. Farber, Pedro C. Avila, Denise Serebrisky, Shannon Thyne, Emerita Brigino‐Buenaventura, William Rodriguez‐Cintron, Śaunak Sen, Rajesh Kumar, Michael A. LeNoir, José Rodríguez‐Santana, Juan C Celedón, Somnath Mukhopadhyay, Uroš Potočnik, Munir Pirmohamed, Katia Verhamme, Michael Kabesch, Colin N. A. Palmer, Daniel B. Hawcutt, Carlos Flores, Anke H. Maitland‐van der Zee, Esteban G. Burchard, Maria Pino‐Yanes
Abstract
This study revealed the novel association of APOBEC3B and APOBEC3C with asthma exacerbations in children treated with ICS and replicated previously identified genomic regions. This contributes to the current knowledge about the multiple genetic markers determining responsiveness to ICS which could lead in the future the clinical identification of those asthma patients who are not able to respond to such treatment.
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