Neuronal branching of sensory neurons is associated with BDNF‐positive eosinophils in atopic dermatitis
Clinical & Experimental Allergy2020Vol. 50(5), pp. 577–584
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Daria Guseva, Urda Rüdrich, Nika Kotnik, Manuela Gehring, Nikolaos Patsinakidis, Konstantin Agelopoulos, Sonja Ständer, Bernhard Homey, Alexander Kapp, Bernhard F. Gibbs, Evgeni Ponimaskin, Ulrike Raap
Abstract
Our results indicate that BDNF-positive eosinophils are also localized in close proximity with nerve fibres in AD, suggesting a functional relationship between BDNF-expressing eosinophils and neuronal projections. These observations suggest that eosinophils may have considerable impact on pruritus by supporting sensory nerve branching.
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