ADRB2 haplotypes and asthma exacerbations in children and young adults: An individual participant data meta‐analysis
Clinical & Experimental Allergy2021Vol. 51(9), pp. 1157–1171
Citations Over TimeTop 19% of 2021 papers
Leila Karimi, Susanne J. H. Vijverberg, Marjolein Engelkes, Natalia Hernandez‐Pacheco, Niloufar Farzan, Patrícia Soares, Maria Pino‐Yanes, Andrea Jorgensen, Celeste Eng, Somnath Mukhopadhyay, Maximilian Schieck, Michael Kabesch, Esteban G. Burchard, Fook Tim Chew, Yang Yie Sio, Uroš Potočnik, Mario Gorenjak, Daniel B. Hawcutt, Colin N. Palmer, Steve Turner, Hettie M. Janssens, Anke H. Maitland‐van der Zee, Katia Verhamme, the PiCA and SysPharmPedia consortia
Abstract
The ADRB2 Arg16 haplotype, presumably mainly driven by the Arg16, increased the risk of asthma exacerbations in patients treated with ICS plus LABA. This finding could be beneficial in ADRB2 genotype-guided treatment which might improve clinical outcomes in asthmatic patients.
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