Beneficial Effect of Tolerogenic Dendritic Cells Pulsed with MOG Autoantigen in Experimental Autoimmune Encephalomyelitis
CNS Neuroscience & Therapeutics2014Vol. 21(3), pp. 222–230
Citations Over TimeTop 10% of 2014 papers
María José Mansilla, Carla Sellès‐Moreno, Sara Fàbregas‐Puig, Joan Amoedo, Juan Navarro‐Barriuso, Aina Teniente‐Serra, Laia Grau‐López, Cristina Ramo‐Tello, Eva Martínez‐Cáceres
Abstract
We found that VitD3-TolDC-MOG treatment showed a beneficial effect, not only decreasing the incidence of the disease but also reducing the severity of the clinical signs mediated by induction of regulatory T cells (Treg), as well as IL-10 production and reduction of Ag-specific lymphoproliferation. Our results support VitD3-TolDC-peptide(s) treatment as a potential strategy to restore tolerance in autoimmune diseases such as MS.
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