P7C3 suppresses astrocytic senescence to protect dopaminergic neurons: Implication in the mouse model of Parkinson’s disease
CNS Neuroscience & Therapeutics2024Vol. 30(7), pp. e14819–e14819
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Yajing Chen, Zengyan Zhu, Yinghui Yan, Hongyang Sun, Guanghui Wang, Xiaohuan Du, Fang Li, Shuwei Yuan, Wenjing Wang, Mei Wang, Chao Gu
Abstract
This study revealed that P7C3 inhibited astrocytic senescence via increased Nrf2/Sirt3-mediated mitophagy and suppression of mitoROS, which further protected against DA neuronal loss. These observations provide a prospective theoretical basis for P7C3 in the treatment of age-associated neurodegenerative diseases, such as PD.
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