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Liver X Receptor Beta Regulates Glial Dynamics and Cortical Network Remodeling in a Freezing Lesion–Cortical Dysplasia Model
CNS Neuroscience & Therapeutics2025Vol. 31(11), pp. e70671–e70671
Zhi Zhang, Di Du, Min Song, Jie Li, Xuebin Dong, Yujiang Mei, Jinwei Zhang, Ming Zhang, Yuan Ma, Sixun Yu, Haifeng Shu, Xin Chen
Abstract
Our findings demonstrate that LXRβ plays a critical role in regulating glial migration, differentiation and cortical network remodeling in the FL-CD model. Pharmacological modulation of LXRβ may offer a novel therapeutic strategy for restoring neural circuit stability in FCD, highlighting its potential as a molecular target for intervention in drug-resistant epilepsy.