Blockage of SLC31A1‐dependent copper absorption increases pancreatic cancer cell autophagy to resist cell death
Cell Proliferation2019Vol. 52(2), pp. e12568–e12568
Citations Over TimeTop 10% of 2019 papers
Ze Yu, Rongtao Zhou, Yicheng Zhao, Yi Pan, Hao Liang, Jin‐San Zhang, Sheng Tai, Liang Jin, Chun‐Bo Teng
Abstract
These findings reveal that copper deprivation-caused cell dormancy and the increase in autophagy is a reason for the poor clinical outcome obtained from copper depletion therapies for cancers. Therefore, the combination of autophagy inhibition and copper depletion is potentially a novel strategy for the treatment of pancreatic cancer and other copper-dependent malignant tumours.
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