PD‐1/PD‐L1 blockade rescue exhausted CD8+ T cells in gastrointestinal stromal tumours via the PI3K/Akt/mTOR signalling pathway
Cell Proliferation2019Vol. 52(3), pp. e12571–e12571
Citations Over TimeTop 10% of 2019 papers
Rui Zhao, Yinghan Song, Yong Wang, Yuqian Huang, Zhigui Li, Yaping Cui, Mengshi Yi, Lin Xia, Wen Zhuang, Xiaoting Wu, Yong Zhou
Abstract
PD-L1 expression was an independent poor prognosis factor in GIST. PD-1/PD-L1 blockade rescued exhausted CD8+ T cells in GIST via the PI3K/Akt/mTOR signalling pathway. In GIST, PD-1/PD-L1 not only function as predictive biomarkers but also improve current therapies as treatment targets.
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