Pin1 promotes pancreatic cancer progression and metastasis by activation of NF‐κB‐IL‐18 feedback loop
Cell Proliferation2020Vol. 53(5), pp. e12816–e12816
Citations Over TimeTop 11% of 2020 papers
Qiqing Sun, Guixiong Fan, Qifeng Zhuo, Weixing Dai, Ye Zeng, Shunrong Ji, Wenyan Xu, Wensheng Liu, Qiangsheng Hu, Zheng Zhang, Mengqi Liu, Xianjun Yu, Xiaowu Xu, Yi Qin
Abstract
Our study improves the understanding of Pin1 in tumour-promoting inflammation in PDAC, which is a hallmark of cancer; Pin1 interacted with p65 in PDAC and enhanced NF-κB signalling and downstream transcriptional activation of IL-18, with increased IL-18 continuously activating NF-κB signalling, which then forms a positive feedback loop.
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