Wedelolactone facilitates Ser/Thr phosphorylation of NLRP3 dependent on PKA signalling to block inflammasome activation and pyroptosis
Cell Proliferation2020Vol. 53(9), pp. e12868–e12868
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Hao Pan, Yuqing Lin, Jianping Dou, Zhen F. Fu, Yanqing Yao, Shanyu Ye, Saixia Zhang, Neng Wang, Aijun Liu, Xican Li, Fengxue Zhang, Dongfeng Chen
Abstract
Our results indicate that wedelolactone promotes the Ser/Thr phosphorylation of NLRP3 to inhibit inflammasome activation and pyroptosis partly through potentiating PKA signalling, thus identifying its potential use for treating MSU-induced peritonitis and gouty arthritis.
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