An update on the roles of circular RNAs in osteosarcoma
Citations Over TimeTop 10% of 2020 papers
Abstract
Osteosarcoma is the most common primary bone malignancy and is a neoplasm thought to be derived from the bone-forming mesenchymal stem cells. Aberrant activation of oncogenes and inactivation of tumour suppressor genes by somatic mutations and epigenetic mechanisms play a pivotal pathogenic role in osteosarcoma. Aside from alterations in these protein-coding genes, it has now been realized that dysregulation of non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and the recently discovered circular RNAs (circRNAs), is crucial to the initiation and progression of osteosarcoma. CircRNAs are single-stranded RNAs that form covalently closed loops and function as an important regulatory element of the genome through multiple machineries. Recently, an increasing number of studies suggested that circRNAs also played critical roles in osteosarcoma. This review summarizes recent development and progression in circRNA transcriptome analysis and their functions in the modulation of osteosarcoma progression.
Related Papers
- → Increased circular RNA UBAP2 acts as a sponge of miR-143 to promote osteosarcoma progression(2017)154 cited
- → Recent Advances of Circular RNAs as Biomarkers for Osteosarcoma(2023)10 cited
- → CIRCULAR RNA – miRNA MEDIATED INTERACTION IN MYOCARDIAL INFARCTION(2021)1 cited
- → Recent advance in role of circular RNA in neurological diseases(2018)
- → [Regulatory mechanism and potential value of circular RNA in nonalcoholic fatty liver disease progression].(2022)