Acid‐sensing ion channels regulate nucleus pulposus cell inflammation and pyroptosis via the NLRP3 inflammasome in intervertebral disc degeneration
Cell Proliferation2020Vol. 54(1), pp. e12941–e12941
Citations Over TimeTop 1% of 2020 papers
Kangcheng Zhao, Ran An, Qian Xiang, Gaocai Li, Kun Wang, Yu Song, Zhiwei Liao, Shuai Li, Wenbin Hua, Xiaobo Feng, Xinghuo Wu, Yukun Zhang, Abhirup Das, Yang Cao
Abstract
Extracellular lactate regulates levels of intercellular reactive oxygen species (ROS) through ASIC1 and ASIC3. ROS activate the NF-κB signalling pathway, thus promoting NLRP3 inflammasome activation and IL-1β release, both of which promote NP degeneration.
Related Papers
- → Inflammasome activation and assembly at a glance(2017)441 cited
- → NLRP3 inflammasome activation triggers gasdermin D–independent inflammation(2021)271 cited
- → Relevance of the Pyroptosis-Related Inflammasome Pathway in the Pathogenesis of Diabetic Kidney Disease(2021)111 cited
- → Does Pyroptosis Play a Role in Inflammasome-Related Disorders?(2022)24 cited
- → [Advances in research on cardiomyocyte pyroptosis mediated by NLRP3 inflammasome and traditional Chinese medicine intervention].(2021)