ERK/Drp1‐dependent mitochondrial fission contributes to HMGB1‐induced autophagy in pulmonary arterial hypertension
Cell Proliferation2021Vol. 54(6), pp. e13048–e13048
Citations Over TimeTop 1% of 2021 papers
Wei Feng, Jian Wang, Xin Yan, Qianqian Zhang, Limin Chai, Qingting Wang, Wenhua Shi, Yuqian Chen, Jin Liu, Zhan Qu, Shaojun Li, Xinming Xie, Manxiang Li
Abstract
HMGB1 promotes PASMCs proliferation/migration and pulmonary vascular remodelling by activating ERK1/2/Drp1/Autophagy/BMPR2/Id1 axis, suggesting that this cascade might be a potential novel target for management of PAH.
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