Carbon monoxide alleviates senescence in diabetic nephropathy by improving autophagy
Cell Proliferation2021Vol. 54(6), pp. e13052–e13052
Citations Over TimeTop 15% of 2021 papers
Li Chen, Guibin Mei, Chunjie Jiang, Xueer Cheng, Dan Li, Ying Zhao, Huimin Chen, Cheng Wan, Ping Yao, Chao Gao, Yuhan Tang
Abstract
These results suggested that CO protects DN mice from renal senescence and function loss via improving autophagy partly mediated by dissociating Beclin-1-Bcl-2 complex, which is possibly ascribed to the degradation of SASP. These findings bring new ideas for the prevention and treatment of DN and the regulation of senescence.
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