Amphiregulin promotes hair regeneration of skin‐derived precursors via the PI3K and MAPK pathways
Cell Proliferation2021Vol. 54(9), pp. e13106–e13106
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Qiumei Lu, Ying Gao, Zhimeng Fan, Xing Xiao, Chen Yu, Yuan Si, D. J. Kong, Shuai Wang, Meijian Liao, Xiaohong Chen, Xusheng Wang, Weiwei Chu
Abstract
By exploiting a 3D co-culture model, we determined that AREG promoted SKP stemness by enhancing both proliferation and hair-inducing capacity through the PI3K and MAPK pathways. These findings suggest AREG therapy as a potentially promising approach for treating alopecia.
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