YTHDF1 promotes mRNA degradation via YTHDF1‐AGO2 interaction and phase separation
Cell Proliferation2021Vol. 55(1), pp. e13157–e13157
Citations Over TimeTop 10% of 2021 papers
Jiong Li, Ke Chen, Xin Dong, Yating Xu, Qi Sun, Honghong Wang, Zhen Chen, Cong Liu, Rong Liu, Zhe Yang, Xiangfei Mei, Rongyu Zhang, Liuping Chang, Zongwen Tian, Jianjun Chen, Kaiwei Liang, Chunjiang He, Mengcheng Luo
Abstract
YTHDF1 recruits AGO2 through the YTH domain. YTHDF1 degrades targeting mRNAs by promoting P-body formation through LLPS. The deletion of YTHDF1 causes the P-body to change from liquid droplets to gel/solid droplets, and form AGO2/RNA patches, resulting in a degradation delay of mRNAs. These findings reveal a previously unrecognized crosstalk between YTHDF1 and AGO2, raising a new sight of mRNA post-transcriptional regulation by YTHDF1.
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