Methylglyoxal is associated with changes in kidney function among individuals with screen‐detected Type 2 diabetes mellitus
Diabetic Medicine2016Vol. 33(12), pp. 1625–1631
Citations Over TimeTop 10% of 2016 papers
Troels Mygind Jensen, Dorte Vistisen, Thomas Fleming, Peter P. Nawroth, Peter Rossing, Marit E. Jørgensen, T. Lauritzen, Annelli Sandbæk, Daniel R. Witte
Abstract
In a population of people with screen-detected Type 2 diabetes, we observed associations between methylglyoxal and markers of renal function: 6-year change in methylglyoxal was inversely associated with 6-year change in eGFR. Also, methylglyoxal at baseline was positively associated with ACR at baseline. Our study lends further support to a role for methylglyoxal in the pathogenesis of diabetic nephropathy.
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