Opposite effects of a glucokinase activator and metformin on glucose‐regulated gene expression in hepatocytes
Diabetes Obesity and Metabolism2017Vol. 19(8), pp. 1078–1087
Citations Over TimeTop 11% of 2017 papers
Ziad H. Al‐Oanzi, Sophia Fountana, Tabassum Moonira, Susan J. Tudhope, John L. Petrie, Ahmed Alshawi, Gillian Patman, Catherine Arden, Helen L. Reeves, Loranne Agius
Abstract
Elevation in hepatocyte G6P and downstream metabolites, with consequent liver Gck repression, is a potential contributing mechanism to the loss of GKA efficacy during chronic therapy. Cell metformin loads within the therapeutic range attenuate the effect of high glucose on G6P and on glucose-regulated gene expression.
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