Persisting plasma proinsulin levels in a cohort of 482 individuals with long‐standing type 1 diabetes mellitus
Diabetes Obesity and Metabolism2025Vol. 27(10), pp. 5566–5575
Citations Over TimeTop 14% of 2025 papers
Douwe F. de Wit, Coco M. Fuhri Snethlage, Rana Minab, Elena Rampanelli, Pleun de Groen, Manon Balvers, Timothy J. McDonald, Richard A. Oram, Bart O. Roep, Daniël H. van Raalte, C. Bruce Verchere, Max Nieuwdorp, Nordin M.J. Hanssen
Abstract
In type 1 diabetes mellitus, proinsulin levels remain detectable long after diagnosis, also in the absence of C-peptide, implying the presence of stressed, yet alive β-cells.
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