Phosphorylation of Smad2/3 at the specific linker threonine residue indicates slow-cycling esophageal stem-like cells before re-entry to the cell cycle
Diseases of the Esophagus2015Vol. 29(2), pp. 1–8
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Yu Takahashi, Toshiro Fukui, Masanobu Kishimoto, Reiko Suzuki, Toshiyuki Mitsuyama, Kimi Sumimoto, Takashi Okazaki, Masayuki Sakao, Yoshiaki Sakaguchi, Katsunori Yoshida, Kazushige Uchida, Akiyoshi Nishio, K Matsuzaki, Kazuichi Okazaki
Abstract
6.889 ± 0.676/cm vs. 4.293 ± 0.659/cm; P < 0.001). We have identified significant expression of pSmad2/3L-Thr in the specific epithelial cells of murine esophagi. We suggest that these cells are slow-cycling epithelial stem-like cells before re-entry to the cell cycle.
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