HIF‐1α and HIF‐2α induce angiogenesis and improve muscle energy recovery
European Journal of Clinical Investigation2014Vol. 44(10), pp. 989–999
Citations Over TimeTop 16% of 2014 papers
Henna Niemi, Krista Honkonen, Petra Korpisalo, Jenni Huusko, Emilia Kansanen, Mari Merentie, Tuomas T. Rissanen, Helder André, Teresa Pereira, Lorenz Poellinger, Kari Alitalo, Seppo Ylä‐Herttuala
Abstract
We conclude that both AdHIF-1α and AdHIF-2α gene transfers induced beneficial angiogenesis in vivo. Transient moderate increases in angiogenesis improved energy recovery after exercise in ischaemic muscles. This study shows for the first time that a moderate increase in angiogenesis is enough to improve tissue energy metabolism, which is potentially a very useful feature for cardiovascular gene therapy.
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