von Willebrand factor D and EGF domains is an evolutionarily conserved and required feature of blastemas capable of multitissue appendage regeneration
Citations Over TimeTop 13% of 2020 papers
Abstract
Regenerative ability varies tremendously across species. A common feature of regeneration of appendages such as limbs, fins, antlers, and tails is the formation of a blastema-a transient structure that houses a pool of progenitor cells that can regenerate the missing tissue. We have identified the expression of von Willebrand factor D and EGF domains (vwde) as a common feature of blastemas capable of regenerating limbs and fins in a variety of highly regenerative species, including axolotl (Ambystoma mexicanum), lungfish (Lepidosiren paradoxa), and Polpyterus (Polypterus senegalus). Further, vwde expression is tightly linked to the ability to regenerate appendages in Xenopus laevis. Functional experiments demonstrate a requirement for vwde in regeneration and indicate that Vwde is a potent growth factor in the blastema. These data identify a key role for vwde in regenerating blastemas and underscore the power of an evolutionarily informed approach for identifying conserved genetic components of regeneration.
Related Papers
- → Lmx-1b and Wnt-7a expression in axolotl limb during development and regeneration(2013)26 cited
- → The effects of retinoic acid on mitosis during tail and limb regeneration in the axolotl larva, Ambystoma mexicanum(1987)13 cited
- Determination of the Blastema Cell Cycle in Regenerating Limbs of the Larval Axolotl, Ambystoma Mexicanum(1976)
- → Symmetrical vascularization patterns in normal and retinoic acid treated limb regenerates of the axolotl, Ambystoma mexicanum(1998)1 cited
- → Gap junctions in the limb regeneration blastema of the axolotl, <i>Ambystoma mexicanum</i>, are not distributed uniformly and are regulated by retinoic acid(1999)