Default mode network changes in multiple sclerosis: a link between depression and cognitive impairment?
European Journal of Neurology2016Vol. 24(1), pp. 27–36
Citations Over TimeTop 10% of 2016 papers
Simona Bonavita, Rosaria Sacco, Sabrina Esposito, Alessandro d’Ambrosio, Marida Della Corte, Daniele Corbo, Renato Docimo, Antonio Gallo, Luigi Lavorgna, Mario Cirillo, Alvino Bisecco, Fabrizio Esposito, Gioacchino Tedeschi
Abstract
In cognitively preserved D-MS patients, FC derangement occurs in the SN, ECN and DMN. In the latter, changes occurring both in the anterior cingulate cortex and PCC suggest that depression in MS may be linked to MS itself and, in particular, to a peculiar pattern of network abnormalities favored by MS pathology through disconnection mechanisms. Reduced FC in the PCC, similar to MS patients with cognitive impairment, suggests a functional link between depression and cognitive impairment in MS.
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