The effect of post‐stroke hyperglycaemia on the levels of brain damage and repair‐related circulating biomarkers: the Glycaemia in Acute Stroke Study II
European Journal of Neurology2019Vol. 26(12), pp. 1439–1446
Citations Over TimeTop 22% of 2019 papers
Laura Otero‐Ortega, M. Gutiérrez‐Fernández, Raquel Gutiérrez-Zúñiga, Rosario Madero-Jarabo, María Alonso de Leciñana, Fernando Laso-García, A. Lisbona, Raquel Delgado‐Mederos, Jaime Gállego-Culleré, Maite Martínez-Zabaleta, Mari Mar Freijo, Juan Carlos Portilla, Antonio Gil-Núñez, Exuperio Díez‐Tejedor, Blanca Fuentes, the GLIAS‐II investigators for the Stroke Project of the Spanish Cerebrovascular Diseases Study Group
Abstract
Post-stroke hyperglycaemia appears to be associated with a negative regulation of BDNF and a different reaction in EPC levels. However, neither BDNF nor EPCs showed significant mediation of the PSH association with IS outcome, and only higher interleukin-6 in the follow-up samples (72-96 h) was related to poor outcomes, independently of PSH status. Further studies are needed to achieve definite conclusions.
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