Adaptive functional reorganization in amyotrophic lateral sclerosis: coexisting degenerative and compensatory changes
European Journal of Neurology2019Vol. 27(1), pp. 121–128
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Malek Abidi, Giovanni de Marco, Annabelle Couillandre, Maryse Feron, Eya Mseddi, Nicolas Termoz, Giorgia Querin, Pierre Pradat, Peter Bede
Abstract
Our findings indicate that, despite the dysfunction of SMA-striatal and SMA-cerebellar networks, cerebello-striatal connectivity increases in ALS indicative of compensatory processes. The coexistence of circuits with decreased and increased connectivity suggests concomitant neurodegenerative and adaptive changes in ALS.
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