Non‐invasive and tracheostomy invasive ventilation in amyotrophic lateral sclerosis: Utilization and survival rates in a cohort study over 12 years in Germany
European Journal of Neurology2020Vol. 28(4), pp. 1160–1171
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Susanne Spittel, André Maier, Dagmar Kettemann, Bertram Walter, Birgit C. P. Koch, Karoline Krause, Jenny Nordén, Christoph Münch, Thomas Meyer
Abstract
Although NIV represents the standard of care, its utilization rate was low. TIV was mainly started without preceding NIV, suggesting that TIV may not be confined to NIV treatment escalation. However, TIV was pursued in a minority of patients who had previously undergone NIV. The survival benefit observed in the patients with NIV was equal to that reported in a controlled pivotal trial, but the prognosis with TIV is highly variable. The determinants of utilization of NIV/TIV and of survival (bulbar syndrome, availability of ventilation-related home nursing, cultural factors) warrant further investigation.
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