TREM2 variants as a possible cause of frontotemporal dementia with distinct neuroimaging features
European Journal of Neurology2021Vol. 28(8), pp. 2603–2613
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Bedia Samancı, Başar Bılgıç, Özlem Gelişin, Fatih Tepgeç, Gamze Güven, Zeynep Tüfekçıoğlu, Merve Alaylıoğlu, Haşmet Hanağası, Hakan Gürvıt, Rita Guerreiro, John Hardy, Murat Emre
Abstract
A combination of white matter changes, enlarged ventricles, atrophy of the caudate nuclei and thinning of the corpus callosum in magnetic resonance imaging strongly suggests NHD in patients with FTD syndrome. Molecular genetic analysis should be performed in suspected cases, and families should receive genetic counseling.
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