Performance of serum neurofilament light chain in a wide spectrum of clinical courses of amyotrophic lateral sclerosis—a cross‐sectional multicenter study
European Journal of Neurology2023Vol. 30(6), pp. 1600–1610
Citations Over TimeTop 10% of 2023 papers
Thomas Meyer, Erma Salkic, Torsten Grehl, Ute Weyen, Dagmar Kettemann, Patrick Weydt, René Günther, Paul Lingor, Jan Christoph Koch, Susanne Petri, Andreas Hermann, Johannes Prudlo, Julian Großkreutz, Petra Baum, Matthias Boentert, Moritz Metelmann, Jenny Nordén, Isabell Cordts, Jochen H. Weishaupt, Johannes Dorst, Albert C. Ludolph, Yasemin Koc, Bertram Walter, Christoph Münch, Susanne Spittel, Marie Dreger, André Maier, Péter Körtvelyessy
Abstract
The finding of moderate sNfL elevation in patients with long ALS duration underlined the favorable prognosis of low sNfL. The strong correlation of sNfL Z score with ALS-PR strengthened its value as progression marker in clinical management and research. The lowering of sNfL in correlation with long TIV duration could reflect a reduction either in disease activity or in the neuroaxonal substrate of biomarker formation during the protracted course of ALS.
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