Serum neurofilament light chain in distinct phenotypes of amyotrophic lateral sclerosis: A longitudinal, multicenter study
European Journal of Neurology2024Vol. 31(9), pp. e16379–e16379
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Thomas Meyer, Marie Dreger, Torsten Grehl, Ute Weyen, Dagmar Kettemann, Patrick Weydt, René Günther, Paul Lingor, Susanne Petri, Jan Christoph Koch, Julian Großkreutz, Annekathrin Rödiger, Petra Baum, Andreas Hermann, Johannes Prudlo, Matthias Boentert, Jochen H. Weishaupt, Wolfgang N. Löscher, Johannes Dorst, Yasemin Koc, Sarah Bernsen, Isabell Cordts, Maximilian Vidovic, Robert Steinbach, Moritz Metelmann, Vera E. A. Kleinveld, Jenny Nordén, Albert C. Ludolph, Bertram Walter, Peggy Schumann, Christoph Münch, Péter Körtvelyessy, André Maier
Abstract
This study underscored the correlation of ALS phenotypes - differentiated for motor neuron involvement and region of onset/propagation - with sNfL, progression, and survival. These phenotypes demonstrated a significant effect on sNfL and should be recognized as independent confounders of sNfL analyses in ALS trials and clinical practice.
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