Targeting of microRNA‐199a‐5p protects against pilocarpine‐induced status epilepticus and seizure damage via SIRT1‐p53 cascade
Epilepsia2016Vol. 57(5), pp. 706–716
Citations Over TimeTop 10% of 2016 papers
Dong Wang, Zhenlu Li, Yukun Zhang, Guangzhi Wang, Minghai Wei, Yan Hu, Shuo Ma, Yue Jiang, Ningwei Che, Xiaofeng Wang, Jihong Yao, Jian Yin
Abstract
The results of this study suggest that silencing of miR-199a-5p exerts a seizure-suppressing effect in rats, and that SIRT1 is a direct target of miR-199a-5p in the hippocampus. The effect of miR-199a-5p on seizures and seizure damage is mediated via down-regulation of SIRT1. The miR-199a-5p/SIRT1 pathway may thus represent a potential target for the prevention and treatment of epilepsy and epileptic damage.
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