The extent of cytochrome P450 3A induction by antiseizure medications: A systematic review and network meta‐analysis
Epilepsia2023Vol. 65(2), pp. 445–455
Citations Over TimeTop 10% of 2023 papers
Abstract
Despite the limited number of studies, our network meta-analysis emphasizes that the magnitude of ASM effects on CYP3A substrate metabolism is a dose-dependent continuum. When possible, ASM classification as inducers should apply cutoff values tailored to the outcome. Prescribers should monitor plasma concentrations or clinical effects of CYP3A substrates and consider selecting concomitant medications accordingly.
Related Papers
- → Neurodevelopment After In Utero Exposure to Phenytoin and Carbamazepine(1994)13 cited
- → Effects of anti‐epileptic drug treatment with carbamazepine or phenytoin on the oral state of children and adolescents(1982)35 cited
- → Carbamazepine vs Phenytoin(1979)43 cited
- → The interaction of denzimol (a new anticonvulsant) with carbamazepine and phenytoin.(1985)12 cited
- → Neurodevelopment After In Utero Exposure to Phenytoin and Carbamazepine(1994)1 cited