Lack of microRNA miR‐150 reduces the capacity of epidermal Langerhans cell cross‐presentation
Citations Over TimeTop 21% of 2012 papers
Abstract
Abstract Micro RNA s (mi RNA s) are evolutionarily conserved small non‐coding RNA s that repress target genes at post‐transcriptional level. Langerhans cells ( LC s) are skin‐residential dendritic cells ( DC s) with a life cycle distinct from other types of DC s. mi RNA deficiency interrupts the homoeostasis and function of epidermal LC s, suggesting the critical roles of mi RNA s in LC development and function. However, the roles of individual mi RNA s in regulating LC development and function remain completely unknown. MiRNA miR‐150 is highly expressed in mature lymphocytes and regulates T ‐ and B ‐cell development and function. Here, we reported that miR‐150 is also expressed in epidermal LC s, and its expression is significantly down‐regulated during in vitro LC maturation. Using a mi R ‐150 knockout mouse model, we found that lack of mi R ‐150 reduces the capacity of LC s to cross‐present a soluble antigen to antigen‐specific CD 8 + T cells, but does not disturb the development, maturation, migration and phagocytic capacity of LC s. Thus, our data indicate that miR‐150 is required for LC cross‐presentation.
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