Antifatigue effects of troxerutin on exercise endurance capacity, oxidative stress and matrix metalloproteinase‐9 levels in trained male rats

Citations Over TimeTop 13% of 2017 papers

Abstract

The aim of this study was to investigate effects of troxerutin (TRX) on endurance capacity, oxidative stress and matrix metalloproteinase-9 (MMP-9) levels in trained male rats. Forty male Wistar rats were divided into five groups. The control (Vehicle) and exercise training (5 days/week) with vehicle treatment (Exercise), exercise training with TRX treatment at 75 (Ex-TRX75), 150 (Ex-TRX150), and 300 mg/kg (Ex-TRX300). The treated groups received TRX by gavage every day while the other groups received water for 30 days. On the 30th day, rats were sacrificed immediately after exhaustive swimming test, and some biochemical parameters were measured. Exhaustion swimming time in the Ex-TRX75, Ex-TRX150 and Ex-TRX300 groups significantly increased 1.2-, 1.93- and 2.1-fold compared to the vehicle group, respectively. TRX significantly increased glucose level (P < 0.05) and reduced creatine kinase activity (P < 0.001) compared to the vehicle and exercise groups. TRX300 significantly reduced alkaline phosphatase and lactate dehydrogenase activities (P < 0.05) and blood urea nitrogen (P < 0.05) and MMP-9 levels (P < 0.05) compared to the vehicle and exercise groups. Additionally, TRX300 and TRX150 significantly increased superoxide dismutase activity compared to the vehicle group (P < 0.05). Our results provide experimental evidence in supporting clinical use of TRX as an effective agent against fatigue.

Related Papers

• → Changes in creatine kinase, lactate dehydrogenase and aspartate aminotransferase in saliva samples after an intense exercise: a pilot study(2018)30 cited
• → The effect of a short burst of exercise on activity values of enzymes in sera of healthy young men(1976)52 cited
• → Age-Dependent Variations of Lactate Dehydrogenase and Creatine Kinase Activities in Water Buffalo Calf Serum(1996)13 cited
• Effect of sex and age on the activities of lactate dehydrogenase and alkaline phosphatase in the lungs of rats.(1986)
• Levels of Serum Creatine Kinase,Lactate Dehydrogenase and Their Iso-enzymes in Low Back Pain Patients(2005)