Transforming growth factor‐β1 inhibits interleukin‐1β‐induced expression of inflammatory genes and Cathepsin S activity in human vascular smooth muscle cells
Fundamental and Clinical Pharmacology2021Vol. 35(6), pp. 979–988
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Nedra Dhaouadi, Ali Nehme, Wissam H. Faour, Patrick Feugier, Catherine Cerutti, Kamel Kacem, Ali H. Eid, Jacques‐Yuan Li, Kazem Zibara
Abstract
TGF-β1 abrogated IL-1β-induced expression of inflammatory genes and elastolytic activity in cultured human vSMCs. Thus, TGF-β1 can play a crucial role in impairing IL-1β-induced vascular inflammation and damage involved in the etiology of cardiovascular diseases.
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