Non–Invasive Vagus Nerve Stimulation for the ACute Treatment of Cluster Headache: Findings From the Randomized, Double‐Blind, Sham‐Controlled ACT1 Study
Headache The Journal of Head and Face Pain2016Vol. 56(8), pp. 1317–1332
Citations Over TimeTop 1% of 2016 papers
Stephen D. Silberstein, Laszlo Mechtler, David Kudrow, Anne H. Calhoun, Candace K. McClure, Joel R. Saper, Eric Liebler, Emily Rubenstein Engel, Stewart J. Tepper, on Behalf of the ACT1 Study Group
Abstract
In one of the largest randomized sham-controlled studies for acute CH treatment, the response rate was not significantly different (vs sham) for the total population; nVNS provided significant, clinically meaningful, rapid, and sustained benefits for eCH but not for cCH, which affected results in the total population. This safe and well-tolerated treatment represents a novel and promising option for eCH. ClinicalTrials.gov identifier: NCT01792817.
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