Amylin
Citations Over TimeTop 16% of 2017 papers
Abstract
Amylin is a 37 amino acid peptide hormone that is closely related to calcitonin gene‐related peptide (CGRP). Amylin and CGRP share a receptor and are reported to have several similar biological actions. Given the important role of CGRP in migraine and intense efforts to develop drugs against this target, it is important to consider potential areas of overlap between the amylin and CGRP systems. This short review provides a brief introduction to amylin biology, the use of an amylin analog to treat diabetes, and consideration of whether amylin could have any role in headache disorders. Finally, this review informs readers about the AMY 1 (amylin subtype 1) receptor, which is a dual receptor for amylin and CGRP and potentially plays a role in the bioactivity of both of these peptides.
Related Papers
- → Vasodilator responses to calcitonin gene-related peptide (CGRP) and amylin in the rat isolated perfused kidney are mediated via CGRP1 receptors.(1994)51 cited
- The Cgrp Family: Calcitonin Gene-Related Peptide (Cgrp), Amylin and Adrenomedullin(1999)
- → Stimulation of calcitonin secretion in the pig by calcitonin gene-related peptide(1991)4 cited
- → Molecular characterization of calcitonin gene-related peptide (CGRP) in a rat medullary thyroid carcinoma cell line(1995)1 cited
- → Calcitonin gene-related peptide (CGRP) and nitric oxide (NO): Are they inhibitory neurotransmitters in the gut?(1995)