Tolvaptan for improvement of hepatic edema: A phase 3, multicenter, randomized, double‐blind, placebo‐controlled trial
Hepatology Research2013Vol. 44(1), pp. 73–82
Citations Over TimeTop 10% of 2013 papers
Isao Sakaida, Seiji Kawazoe, Kozo Kajimura, Takafumi Saito, Chiaki Okuse, Koichi Takaguchi, Mitsuru Okada, Kiwamu Okita, ASCITES‐DOUBLEBLIND Study Group
Abstract
Add-on therapy with tolvaptan was effective for the treatment of hepatic edema and ascites-related clinical symptoms. Furthermore, tolvaptan is expected to improve low serum sodium concentration and to exert its effect regardless of serum albumin level. Add-on therapy with tolvaptan is therefore considered to be a novel therapeutic option for hepatic edema.
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