Abnormality of autophagic function and cathepsin expression in the liver from patients with non‐alcoholic fatty liver disease
Hepatology Research2013Vol. 44(9), pp. 1026–1036
Citations Over TimeTop 10% of 2013 papers
Yuka Fukuo, Shunhei Yamashina, Hiroshi Sonoue, Atsushi Arakawa, Eisuke Nakadera, Tomonori Aoyama, Akira Uchiyama, Kazuyoshi Kon, Kenichi Ikejima, Sumio Watanabe
Abstract
These results indicate that a decrease in hepatic cathepsin expression in NAFLD is associated with autophagic dysfunction. Hepatic inflammation correlates with autophagic dysfunction in NAFLD. These findings indicate that the suppression of autophagic proteolysis by hepatic steatosis is involved in the pathogenesis of NAFLD.
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