Gleason grade 4 prostate adenocarcinoma patterns: an interobserver agreement study among genitourinary pathologists
Histopathology2016Vol. 69(3), pp. 441–449
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Charlotte F. Kweldam, Daan Nieboer, Ferrán Algaba, Mahul B. Amin, Daniel M. Berney, Athanase Billis, David G. Bostwick, Lukas Bubendorf, Liang Cheng, Éva Compérat, Brett Delahunt, Lars Egevad, Andrew Evans, Donna E. Hansel, Peter A. Humphrey, Glen Kristiansen, Theodorus van der Kwast, Cristina Magi‐Galluzzi, Rodolfo Montironi, George J. Netto, Hemamali Samaratunga, John R. Srigley, Puay Hoon Tan, Murali Varma, Ming Zhou, Geert J.L.H. van Leenders
Abstract
Consensus on Gleason grade 4 growth pattern was predominantly reached on cribriform and glomeruloid patterns, but rarely on ill-formed and fused glands. The complex fused glands seem to constitute a borderline pattern of unknown prognostic significance on which a consensus could not be reached.
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