Analysis of papillary urothelial carcinomas of the bladder with grade heterogeneity: supportive evidence for an early role of CDKN2A deletions in the FGFR3 pathway
Histopathology2016Vol. 70(2), pp. 281–289
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Michelle R. Downes, Berber Weening, Bas W.G. van Rhijn, Cherry Have, Kilian M. Treurniet, Theodorus van der Kwast
Abstract
Our findings show that grade heterogeneity in urothelial carcinoma is characterized by increased MIB-1 labelling, and particularly in the FGFR3 mutant pathway, with homozygous deletions of CDKN2A in low- and high-grade areas. This would suggest that CDKN2A deletion occurs prior to grade progression and supports the current convention to assign the highest grade to urothelial carcinomas with grade heterogeneity.
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