Interleukin‐17 and ischaemic stroke

Immunology2020Vol. 162(2), pp. 179–193

Citations Over TimeTop 10% of 2020 papers

Qiaohui Zhang, Yan Liao, Zhenquan Liu, Yajie Dai, Yunxin Li, Yue Li, Yibo Tang

Abstract

Interleukin-17 (IL-17) is a cytokine family that includes 6 members, IL-17A through IL-17F, most of them are reported to have pro-inflammatory role. Through binding to their receptors (IL-17Rs), IL-17 activates the intracellular signalling pathways to play an important role in autoimmune diseases, including rheumatoid arthritis (RA) and multiple sclerosis (MS). Ischaemic stroke is a complex pathophysiological process mainly caused by regional cerebral ischaemia. Inflammatory factors contribute to the physiological process of stroke that leads to poor prognosis. IL-17 plays a crucial role in promoting inflammatory response and inducing secondary injury in post-stroke. Though immune cells and inflammatory factors have been reported to be involved in the damage of stroke, the functions of IL-17 in this process need to be elucidated. This review focuses on the pathological modulation and the mechanism of IL-17 family in ischaemic stroke and seeking to provide new insights for future therapies.

Citations Over TimeTop 10% of 2020 papers

Abstract

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