Differential modulation of human basophil functions through prostaglandin D2 receptors DP and chemoattractant receptor‐homologous molecule expressed on Th2 cells/DP2
Clinical & Experimental Allergy2004Vol. 34(8), pp. 1283–1290
Citations Over TimeTop 10% of 2004 papers
Chitose Yoshimura-Uchiyama, Motoyasu Iikura, Masao Yamaguchi, Hiroyuki Nagase, Akira Ishii, Kouji Matsushima, Kazuhiko Yamamoto, Michitaka Shichijo, Kevin B. Bacon, Koichi Hirai
Abstract
CRTH2/DP2 is primarily responsible for the pro-inflammatory effects of PGD2 on human basophils, while DP introduces negative signals capable of antagonizing the effects of CRTH2/DP2 in these cells. The effects of PGD2 on longevity imply a mechanism(s) other than via DP or CRTH2/DP2. CRTH2/DP2 on basophils may afford opportunities for therapeutic targeting in allergic inflammation.
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