Loss of response to melatonin treatment is associated with slow melatonin metabolism
Journal of Intellectual Disability Research2010Vol. 54(6), pp. 547–555
Citations Over TimeTop 16% of 2010 papers
Wiebe Braam, Ingeborg M. van Geijlswijk, Henry Keijzer, Marcel G. Smits, Robert Didden, Leopold Curfs
Abstract
We hypothesise that loss of response to melatonin treatment can be caused by slow metabolisation of exogenous melatonin. As melatonin is metabolised in the liver almost exclusively by cytochrome P450 enzyme CYP1A2, this slow melatonin metabolism is probably due to decreased activity/inducibility of CYP1A2. In patients with loss of response to melatonin, a melatonin clearance test should be considered and a considerably dose reduction is advised.
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