Research Review: Polygenic methods and their application to psychiatric traits
Journal of Child Psychology and Psychiatry2014Vol. 55(10), pp. 1068–1087
Citations Over TimeTop 1% of 2014 papers
Naomi R. Wray, Sang Lee, Divya Mehta, Anna A. E. Vinkhuyzen, Frank Dudbridge, Christel M. Middeldorp
Abstract
Increasing the sample size for genome wide association studies of psychiatric disorders will lead to the identification of more associated genetic variants, as already found for schizophrenia. These loci provide the starting point of functional analyses that might eventually lead to new prevention and treatment options and to improved biological validity of diagnostic constructs. Polygenic analyses will contribute further to our understanding of complex genetic traits as sample sizes increase and as sample resources become richer in phenotypic descriptors, both in terms of clinical symptoms and of nongenetic risk factors.
Related Papers
- → The endophenotype concept in psychiatric genetics(2006)480 cited
- → Revealing the missing heritability via cross-validated genome-wide association studies(2013)1 cited
- [Neurocognitive endophenotypes in psychiatric genetics].(2014)
- → Supplemental Material for A Meta-Analytic Evaluation of the Endophenotype Hypothesis: Effects of Measurement Paradigm in the Psychiatric Genetics of Impulsivity(2014)
- → Genetic Architecture of Neurological Disorders and Their Endophenotypes: Insights from Genetic Association Studies(2024)