Research Review: Do motor deficits during development represent an endophenotype for schizophrenia? A meta‐analysis
Journal of Child Psychology and Psychiatry2015Vol. 57(4), pp. 446–456
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Birgitte Klee Burton, Carsten Hjorthøj, Jens Richardt M. Jepsen, Anne Amalie Elgaard Thorup, Merete Nordentoft, Kerstin Jessica Plessen
Abstract
Motor deficits during development likely represent an endophenotype for schizophrenia, although its specificity is limited in relation to other serious mental disorders. It holds promise as a low cost domain for early risk detection, although it will have to be combined with other indicators to achieve clinically usable prediction accuracy. Impaired coordination was the most robust result with a moderate effect size and lack of heterogeneity and publication bias.
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