Evaluation of two histological classifications for actinic keratoses – PRO classification scored highest inter‐rater reliability
Journal of the European Academy of Dermatology and Venereology2019Vol. 33(6), pp. 1092–1097
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Lutz Schmitz, G. Gupta, Markus Stücker, Martin Doerler, Thilo Gambichler, Julia Welzel, Rolf‐Markus Szeimies, E. Bierhoff, Eggert Stockfleth, Thomas Dirschka
Abstract
Histological classification of basal growth pattern (PRO) showed higher inter-rater reliability compared to the established classification of atypical keratinocytes throughout epidermal layers. Moreover, experienced dermatopathologists considered basal proliferation to be more important in terms of progression risk than upwards directed growth patterns. It should be considered to classify AKs according to their basal proliferation pattern (PRO I-III).
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