Inferring signalling networks from images
Journal of Microscopy2013Vol. 252(1), pp. 1–7
Citations Over Time
Abstract
The mapping of signalling networks is one of biology's most important goals. However, given their size, complexity and dynamic nature, obtaining comprehensive descriptions of these networks has proven extremely challenging. A fast and cost-effective means to infer connectivity between genes on a systems-level is by quantifying the similarity between high-dimensional cellular phenotypes following systematic gene depletion. This review describes the methodology used to map signalling networks using data generated in the context of RNAi screens.
Related Papers
- → Abiotic stress signalling pathways: specificity and cross-talk(2001)972 cited
- → Sugar sensing and signalling networks in plants(2005)166 cited
- → Ethylene signalling and response pathway: a unique signalling cascade with a multitude of inputs and outputs(2005)91 cited
- → Early events in signalling by interferons(1993)187 cited
- → Reactive Oxygen Species as Signalling Molecules(2005)53 cited